Head-to-head · WeighScore
1st Optimal vs MadeMed
The verdict
MadeMed takes it — 80.4/100 to 61.6/100.
MadeMed grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Publishes its price at every single dose, so what a titrated dose costs is knowable on day one.
We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.
Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | 1st Optimal | MadeMed |
|---|---|---|
| WeighScore | 61.6/100 | 80.4/100 |
| Grade | C | B− |
| Scorecard rank | #288 | #30 |
| Semaglutide | Not disclosed | $239/mo quarterly (from $199/mo on 6 months) |
| Tirzepatide | Not disclosed | $399/mo quarterly (from $369/mo on 6 months) |
| Coverage | Coverage not published | 40 states |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Yes |
Graded #288 · C
Strengths
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Where it loses points
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Graded #30 · B−
Strengths
- One flat price at every dose, published dose by dose — semaglutide 0.25–2.4mg, tirzepatide 2.5–15mg
- LegitScript verified, with board-certified physician review and US compounding pharmacies
- Full refund minus a $39 visit fee if you are not prescribed, stated before checkout
- Oral semaglutide and oral tirzepatide alongside the injections; free overnight shipping with supplies
Where it loses points
- The most expensive tirzepatide here at $399/mo quarterly
- 40 states rather than nationwide
- No published recurring lab programme
- Ships one vial every two months, a less flexible cadence than a monthly refill
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.