Head-to-head · WeighScore
Signos vs Tryozi
The verdict
Too close to call — both grade 61.4/100 (C).
Signos and Tryozi land on the same WeighScore, so neither clears the other on our six graded dimensions. Signos sits one line higher on the board (#294 vs #295) on the underlying tiebreak, but it's a genuine coin-flip — pick on the factors and prices that matter most to you below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Signos | Tryozi |
|---|---|---|
| WeighScore | 61.4/100 | 61.4/100 |
| Grade | C | C |
| Scorecard rank | #294 | #295 |
| Semaglutide | $199/mo (6-month plan, compounded) | $279/mo (compounded) |
| Tirzepatide | $199/mo (starting dose, compounded) | $379/mo (compounded) |
| Coverage | Coverage not published | All 50 states |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Injection only |
Graded #294 · C
Strengths
- Bundles compounded GLP-1 (semaglutide) with an FDA-cleared CGM and app — glucose-guided weight loss, not just medication
- Starting at $199/mo on a 6-month program, with the CGM included at no extra cost
- Free rapid shipping; HSA/FSA eligible
- Real-time glucose insights and app coaching to help sustain results after GLP-1
Where it loses points
- Compounded GLP-1s are not FDA-approved finished products
- Headline price is a 6-month-program rate, not month-to-month
- Only semaglutide is shown in the program; tirzepatide availability is not confirmed
- Compounding pharmacy partner and state availability are not published on the landing page
Graded #295 · C
Strengths
- Names all four of its 503A compounding pharmacies: RedRock, Health Warehouse, Precision Medicine and Triad Rx
- Price does not increase as your dose increases, stated plainly on the pricing page
- Full total shown before payment, with the first-month discount and the ongoing rate both visible
- States plainly that compounded medications are not FDA-approved, a disclosure many competitors omit
- LegitScript certification verified against the issued seal, not just the badge
Where it loses points
- Headline $139 is a first-month half-price offer; the ongoing rate is $279
- Multi-week plans are billed once as a single upfront charge, not as a lower monthly rate
- Plans ship every 4 weeks, so a 52-week plan is 13 shipments rather than 12 months
- No refund policy detail is published on the pricing page itself
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.