Head-to-head · WeighScore
LifeMD vs Lyfe Rx
The verdict
Lyfe Rx takes it — 58.3/100 to 57.8/100, but only just.
Lyfe Rx grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Lyfe Rx offers compounded semaglutide ($289) and compounded tirzepatide ($399). LifeMD is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | LifeMD | Lyfe Rx |
|---|---|---|
| WeighScore | 57.8/100 | 58.3/100 |
| Grade | C | C |
| Scorecard rank | #390 | #375 |
| Semaglutide | Not disclosed | $225/mo (compounded) |
| Tirzepatide | Not disclosed | $299/mo (compounded) |
| Coverage | All 50 states | Coverage not published |
| Brand-name access | Yes | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #390 · C
Strengths
- Telehealth convenience
- Physician-supervised program
Where it loses points
- Brand-name GLP-1 only — no lower-cost compounded option
- Monthly program & provider fee ($149/mo, $75 first month) is separate from medication cost
Graded #375 · C
Strengths
- Both compounded semaglutide and tirzepatide available
- Delivery to all 50 states with 1–3 day pharmacy turnaround
Where it loses points
- No visible LegitScript or PCAB accreditation
- Also sells non-prescription supplements ('Tirzepatide Weight Loss Supplement', 'Lipo Burn')
- Shopify-based e-commerce storefront — less clinical infrastructure
- FDA issued this company a warning letter dated 9 September 2025; the letter is public in FDA's warning-letter database
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.