Head-to-head · WeighScore
Immortals vs Signos
The verdict
Immortals takes it — 61.8/100 to 61.4/100, but only just.
Immortals grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Immortals is a LegitScript-certified longevity telehealth platform founded by Bryan Johnson, offering compounded semaglutide (Semaglutide/Glycine/B12) and tirzepatide (Tirzepatide/Glycine/B12) as microdose… Signos is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Immortals | Signos |
|---|---|---|
| WeighScore | 61.8/100 | 61.4/100 |
| Grade | C | C |
| Scorecard rank | #284 | #293 |
| Semaglutide | $167/mo (microdose tier, compounded) | $199/mo (6-month plan, compounded) |
| Tirzepatide | $180/mo (microdose tier, compounded) | $199/mo (starting dose, compounded) |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Injection only |
Graded #284 · C
Strengths
- LegitScript certified (ID 50458743) with board-certified U.S. physician review within 72 hours
- Physician consult + prescription bundled in price — 'You pay for treatment. That's it' with no added fees
- Competitive pricing: semaglutide microdose from $167/month, tirzepatide from $180/month (promotional)
- Unlimited provider messaging for 12 months included; video consults available
- Founded by Bryan Johnson and Kate Tolo; clinical lead Dr. Carl Seger, M.D. (preventive/longevity medicine)
Where it loses points
- Microdose framing uses sub-clinical doses — lower weight-loss efficacy than standard GLP-1 protocols
- Quarterly commitment only — 3-month minimum, paid upfront ($501–$540/quarter); no monthly flexibility
- State availability not publicly listed; 'eligible U.S. states' with no specific state list
- Labs not included; baseline bloodwork protocol not disclosed on any public page
- Compounding pharmacy not named; no 503A/503B accreditation details disclosed
Graded #293 · C
Strengths
- Bundles compounded GLP-1 (semaglutide) with an FDA-cleared CGM and app — glucose-guided weight loss, not just medication
- Starting at $199/mo on a 6-month program, with the CGM included at no extra cost
- Free rapid shipping; HSA/FSA eligible
- Real-time glucose insights and app coaching to help sustain results after GLP-1
Where it loses points
- Compounded GLP-1s are not FDA-approved finished products
- Headline price is a 6-month-program rate, not month-to-month
- Only semaglutide is shown in the program; tirzepatide availability is not confirmed
- Compounding pharmacy partner and state availability are not published on the landing page
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.