Head-to-head · WeighScore
Defy Medical vs Roen Rx
The verdict
Defy Medical takes it — 60.2/100 to 59.2/100, but only just.
Defy Medical grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Defy Medical is a long-running telehealth clinic, best known for hormone replacement, that also prescribes GLP-1 medications for weight loss. Roen Rx is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Defy Medical | Roen Rx |
|---|---|---|
| WeighScore | 60.2/100 | 59.2/100 |
| Grade | C | C |
| Scorecard rank | #325 | #348 |
| Semaglutide | Not disclosed | $151/mo (3-month plan, plus a separate fee, compounded) |
| Tirzepatide | Not disclosed | $216/mo (plus a separate fee, compounded) |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Compounded only | Yes |
| Oral / sublingual | Yes | Injection only |
Graded #325 · C
Strengths
- Multiple GLP-1 options: semaglutide, tirzepatide, liraglutide
- Offers injection, ODT, and oral drop delivery forms
- Comprehensive blood testing and named medical director
- Established clinic with strong Trustpilot review volume
Where it loses points
- GLP-1 pricing not published on the website
- States served and shipping limits not disclosed
- Compounded versus brand status not stated online
- Lab-heavy, consult-first model may cost more upfront
Graded #348 · C
Strengths
- Insurance coordination for brand-name GLP-1s — as low as $25/mo
- Both compounded and brand-name options
- LegitScript approved with Compounded USA badge
- Compounded semaglutide from $151/mo quarterly
- Also offers primary care, mental health, and other specialties
Where it loses points
- State availability not publicly disclosed
- Insurance coordination may not work for all plans
- Broader platform (ED, hair loss, skincare, birth control)
- Requires a separate membership (first month $39); GLP-1 medications are NOT included in the membership fee - medication is billed on top
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.