Head-to-head · WeighScore
Bionomy Health vs Signos
The verdict
Bionomy Health takes it — 66.6/100 to 61.4/100.
Bionomy Health grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Bionomy Health is a physician-led, direct-to-consumer men's telehealth service selling compounded GLP-1 weight-loss medication alongside testosterone, peptides and longevity protocols.
We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.
Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Bionomy Health | Signos |
|---|---|---|
| WeighScore | 66.6/100 | 61.4/100 |
| Grade | C | C |
| Scorecard rank | #182 | #293 |
| Semaglutide | $189/mo (starting dose, compounded) | $199/mo (6-month plan, compounded) |
| Tirzepatide | $249/mo (compounded) | $199/mo (starting dose, compounded) |
| Coverage | 48 states | Coverage not published |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #182 · C
Strengths
- Cancellation is genuinely unconditional: no subscription, no card on file, no auto-renewal, no cancellation fee — you pay per refill
- Prices are published before intake on a dedicated GLP-1 page, and the same figures appear in the site's own llms.txt
- Available in 48 states
Where it loses points
- The $189 is a starting rate, not a flat one: the page says 'From', the product card says 'Starter', and doses are titrated every four weeks with no published price for the dose you end up on
- The homepage says muscle preservation is 'included' while the GLP-1 page sells a Muscle Preserve Pack at $109/mo as a separate line item
- No FDA-approved pathway and no oral route — the site does not mention Wegovy, Ozempic, Zepbound or Mounjaro at all
- Not available in Alaska or Hawaii
- Compounded semaglutide and tirzepatide are not FDA-approved finished products
Graded #293 · C
Strengths
- Bundles compounded GLP-1 (semaglutide) with an FDA-cleared CGM and app — glucose-guided weight loss, not just medication
- Starting at $199/mo on a 6-month program, with the CGM included at no extra cost
- Free rapid shipping; HSA/FSA eligible
- Real-time glucose insights and app coaching to help sustain results after GLP-1
Where it loses points
- Compounded GLP-1s are not FDA-approved finished products
- Headline price is a 6-month-program rate, not month-to-month
- Only semaglutide is shown in the program; tirzepatide availability is not confirmed
- Compounding pharmacy partner and state availability are not published on the landing page
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.