Head-to-head · WeighScore
1st Optimal vs ZYP Medical
The verdict
ZYP Medical takes it — 74.6/100 to 61.6/100.
ZYP Medical grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. ZYP Medical is a men's-health-oriented telehealth practice prescribing compounded GLP-1 medications for weight loss across six states.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | 1st Optimal | ZYP Medical |
|---|---|---|
| WeighScore | 61.6/100 | 74.6/100 |
| Grade | C | C |
| Scorecard rank | #288 | #62 |
| Semaglutide | Not disclosed | $150/mo |
| Tirzepatide | Not disclosed | $233/mo |
| Coverage | Coverage not published | 6 states |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Yes |
Graded #288 · C
Strengths
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Where it loses points
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Graded #62 · C
Strengths
- Transparent flat-rate pricing including medication and shipping with no hidden fees
- Low $50 initial one-hour consultation
- Offers both injectable and oral tirzepatide options
- No membership fees and pricing decreases as treatment progresses
- Care from a board-certified family nurse practitioner
Where it loses points
- Compounded medications are not FDA-approved
- Available in only six states (NE, IA, SD, KS, CO, AZ)
- Cash-pay only; no insurance noted
- No named compounding pharmacy partner disclosed
- No LegitScript certification shown on site
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.