Head-to-head · WeighScore
1st Optimal vs Zeuss
The verdict
Zeuss takes it — 68.9/100 to 61.6/100.
Zeuss grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Zeuss is a multi-vertical telehealth platform offering compounded semaglutide and tirzepatide for weight loss alongside TRT, HRT, skin, and hair services.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | 1st Optimal | Zeuss |
|---|---|---|
| WeighScore | 61.6/100 | 68.9/100 |
| Grade | C | C |
| Scorecard rank | #291 | #143 |
| Semaglutide | Not disclosed | $125/mo (compounded) |
| Tirzepatide | Not disclosed | $175/mo (compounded) |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #291 · C
Strengths
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Where it loses points
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Graded #143 · C
Strengths
- One-time-purchase model with no subscription — genuinely rare among DTC GLP-1 providers
- Publishes the FDA compounded-medication disclaimer
- Names both 503A and 503B compounding pathways — uncommon transparency
- Bundled pricing covers provider review, meds, and cold-chain shipping with no hidden fees
- Full refund if a physician can't prescribe
Where it loses points
- 503A pharmacy partner not named (only generic '503A and 503B state-licensed' framing)
- LegitScript certification not mentioned
- No named medical director or physician leadership
- Full states-served list not disclosed
- Corporate legal entity not disclosed
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.