Head-to-head · WeighScore
1st Optimal vs PeptidesRx
The verdict
PeptidesRx takes it — 64.1/100 to 61.6/100.
PeptidesRx grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. PeptidesRx is a Fort Worth, TX-based licensed telehealth platform offering physician-supervised compounded semaglutide, tirzepatide, and a broader prescription peptide menu.
We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.
Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | 1st Optimal | PeptidesRx |
|---|---|---|
| WeighScore | 61.6/100 | 64.1/100 |
| Grade | C | C |
| Scorecard rank | #291 | #246 |
| Semaglutide | Not disclosed | $169/mo (0.25 mg dose, compounded) |
| Tirzepatide | Not disclosed | $309/mo (2.5 mg dose, compounded) |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #291 · C
Strengths
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Where it loses points
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Graded #246 · C
Strengths
- Compliance-focused positioning vs gray-market vendors
- Board-certified medical director
- Transparent pricing with no surprise fees
- Real prescriptions, not research-chemical channel
Where it loses points
- Smaller scale than Henry Meds or Hims
- Wide peptide menu may distract from GLP-1 focus
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.