Head-to-head · WeighScore
1st Optimal vs Harmony Wellness Clinic
The verdict
1st Optimal takes it — 61.6/100 to 60.9/100, but only just.
1st Optimal grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. 1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Harmony Wellness Clinic is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | 1st Optimal | Harmony Wellness Clinic |
|---|---|---|
| WeighScore | 61.6/100 | 60.9/100 |
| Grade | C | C |
| Scorecard rank | #288 | #308 |
| Semaglutide | Not disclosed | $200/mo (starting dose, compounded) |
| Tirzepatide | Not disclosed | $250/mo (starting dose, compounded) |
| Coverage | Coverage not published | 36 states |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #288 · C
Strengths
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Where it loses points
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Graded #308 · C
Strengths
- LegitScript certified with licensed APRN-CNP clinical oversight by Kristina Stout
- Two compounded GLP-1 options: semaglutide+B12 (5 dose levels) and tirzepatide+B12 (6 dose levels)
- Partners with four named 503A compounding pharmacies for a transparent supply chain
- Competitive starting prices: $200/month for semaglutide and $250/month for tirzepatide
- Telehealth services available in 36 states via the Optimantra online patient portal
Where it loses points
- 36-state coverage — many states including some large markets not served
- Care led by APRN-CNP, not an MD or DO; no physician name disclosed
- Pricing scales with dose level up to $300/month (sema) and $450/month (tirz)
- Labs not mentioned or included on any public page — baseline bloodwork protocol unknown
- No coaching or lifestyle program disclosed beyond clinical dose management
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.