Head-to-head · WeighScore
1st Optimal vs ARSYNL Rx
The verdict
1st Optimal takes it — 61.6/100 to 59.1/100.
1st Optimal grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. 1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets.
We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.
Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | 1st Optimal | ARSYNL Rx |
|---|---|---|
| WeighScore | 61.6/100 | 59.1/100 |
| Grade | C | C |
| Scorecard rank | #288 | #350 |
| Semaglutide | Not disclosed | $233/mo (compounded) |
| Tirzepatide | Not disclosed | $366/mo (compounded) |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #288 · C
Strengths
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Where it loses points
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Graded #350 · C
Strengths
- Offers compounded semaglutide and tirzepatide, including a needle-free tirzepatide hypospray option
- Veteran-founded telehealth with clinician-prescribed, personalized treatment
- Multi-service platform — also covers hair restoration, TRT, sexual health, and longevity
- Medications shipped discreetly to your home
Where it loses points
- Pricing is not shown until you select a product (product pages sit behind a bot-verification gate)
- Compounded GLP-1s are not FDA-approved finished products
- Compounding pharmacy partner and exact state coverage are not disclosed on the site
- No LegitScript certification visible on the accessible pages
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.