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Head-to-head · WeighScore

Prime Health vs SkyRx

Prime Health
Graded #344

Higher grade

vs+0.5
SkyRx
Graded #353

Lower grade

The verdict

Prime Health takes it — 59.4/100 to 58.9/100, but only just.

Prime Health grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Prime Health (joinprimehealth.com) is a LegitScript-certified GLP-1 telehealth platform offering compounded semaglutide and tirzepatide for weight loss. SkyRx is close behind and may still be the better fit — see the factor split below.

We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.

Factor by factor

The same six graded dimensions, side by side. See the methodology.

Cost valueSkyRx +14
42
56
Dose & formulationSkyRx +7
64
71
Clinical oversightPrime Health +6
74
68
Labs & monitoringPrime Health +13
65
52
FulfillmentPrime Health +5
69
64
Contract termsPrime Health +21
41
20
Prime Health · left barSkyRx · right bar

The numbers

MetricPrime HealthSkyRx
WeighScore59.4/10058.9/100
GradeCC
Scorecard rank#344#353
Semaglutide$299/mo (compounded)$199/mo (all doses, 12-month plan, compounded)
Tirzepatide$399/mo (compounded)Not disclosed
CoverageCoverage not publishedCoverage not published
Brand-name accessCompounded onlyCompounded only
Oral / sublingualInjection onlyYes
Prime Health

Graded #344 · C

Strengths

  • LegitScript-certified platform
  • Flat pricing that does not rise as dosage increases
  • Bundle includes medication, labs, shipping, and unlimited clinician access
  • Money-back guarantee of at least 10% body-weight loss in 4 months
  • Fast 24-hour prescription review and 5-7 day delivery

Where it loses points

  • Compounded medications only; no FDA-approved brand options listed
  • Not available in Louisiana
  • Care delivered through third-party clinician groups, not in-house
  • Named compounding pharmacy not disclosed
  • No insurance accepted
SkyRx

Graded #353 · C

Strengths

  • All-inclusive 199 dollars per month covers medication, supplies, doctor visit and shipping
  • Offers both injectable and oral semaglutide, dispensed by FDA-registered 503B pharmacies
  • Same-day shipping for orders before 2pm ET in temperature-controlled packaging

Where it loses points

  • 199 dollars pricing requires a 12-month subscription paid upfront
  • Tirzepatide only listed as coming soon
  • GLP-1s not yet available in all 50 states; specific states not listed

Also worth a look

Neither is our top-graded pick — CoreAge Rx leads the scorecard

Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.

Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.

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