Head-to-head · WeighScore
PlexusDx vs Rylo Health
The verdict
PlexusDx takes it — 67.7/100 to 64.7/100.
PlexusDx grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. PlexusDx (plexusdx.com) is a US GLP-1 telehealth platform offering compounded weight-loss medications with licensed providers in all 50 states.
We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.
Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | PlexusDx | Rylo Health |
|---|---|---|
| WeighScore | 67.7/100 | 64.7/100 |
| Grade | C | C |
| Scorecard rank | #162 | #240 |
| Semaglutide | $149/mo (starting dose, compounded) | $149/mo (promotional rate, compounded) |
| Tirzepatide | $249/mo (starting dose, compounded) | $249/mo (compounded) |
| Coverage | All 50 states | All 50 states |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Injection only |
Graded #162 · C
Strengths
- Licensed providers available in all 50 states
- Range of options including low-cost microdose GLP-1 from $129/mo
- Optional Precision Peptide genetic panel adds a personalization angle
- Independent clinician review via state-licensed telehealth platform
- Compounded medications from state-licensed pharmacies
Where it loses points
- Compounded medications only; no FDA-approved brand options
- Specific compounding pharmacies not named
- Genetic-panel upsell may not add clinical value for everyone
- Tirzepatide pricing from $249/mo is higher than budget rivals
- No insurance accepted
Graded #240 · C
Strengths
- Names its dispensing pharmacy in full, with address and phone: VialsRX in Houston, Texas
- Names its medical group, Lone Star Virtual Health PLLC, and gives a provider contact
- Standard prices published openly alongside the promotional rate, so the real ongoing cost is visible
- Cancel in one click from the patient portal, with no contracts and no cancellation fees
- Peptide line priced openly, including NAD+ and sermorelin
Where it loses points
- Headline $100 and $160 rates are limited to the first 20 patients; standard rates are $149 and $249
- No LegitScript certification is claimed or displayed
- Several peptide products are advertised as coming soon rather than available
- No published refund policy beyond the no-cancellation-fee statement
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.