Head-to-head · WeighScore
Open Water Rx vs Ryze Rx
The verdict
Open Water Rx takes it — 58.8/100 to 58.2/100, but only just.
Open Water Rx grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Open Water Rx is a telehealth platform positioned around GLP-1 weight loss and longevity, per its own site. Ryze Rx is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Open Water Rx | Ryze Rx |
|---|---|---|
| WeighScore | 58.8/100 | 58.2/100 |
| Grade | C | C |
| Scorecard rank | #360 | #376 |
| Semaglutide | $249/mo (compounded) | $199/mo (starting dose, 3 month plan, compounded) |
| Tirzepatide | $339/mo (compounded) | $199/mo (starting dose, 3 month plan, compounded) |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Yes | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #360 · C
Strengths
- Combines weight-loss and longevity verticals in one brand
- Established brand domain
Where it loses points
- Limited public data — most details are gated behind signup or rendered only in JavaScript
- Pricing not disclosed
- GLP-1 options (semaglutide vs. tirzepatide, compounded vs. brand, injection vs. oral) not stated
- States-served list not disclosed
- Pharmacy partner not named
Graded #376 · C
Strengths
- Compounded semaglutide and tirzepatide both $199/mo, with $499/$799 three-month bundles
- Physician consultation, ongoing clinical support and discreet shipping included with each prescription
- Broad catalog beyond GLP-1: TRT plus peptides (BPC-157, sermorelin, NAD+, retatrutide and more)
- Free shipping, 24hr prescription turnaround, FSA/HSA eligible; care advertised in all 50 states
Where it loses points
- Terms, Privacy Policy and HIPAA notice are dead links - no legal entity, refund policy or governing law disclosed
- Pharmacy partners not named - only 'US-licensed compounding pharmacies'
- Homepage advertises GLP-1s 'from $149/mo' but the catalog lists $199/mo
- On-site '4.9/5, 2,400+ reviews' is self-reported, not an independently verified rating
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.