Head-to-head · WeighScore
Metabolyz vs Open Water Rx
The verdict
Metabolyz takes it — 59.6/100 to 58.8/100, but only just.
Metabolyz grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Metabolyz is a nationwide GLP-1 telehealth platform offering three compounded programs — standard semaglutide, dual-agonist tirzepatide, and a microdose protocol for patients near goal weight or intolerant… Open Water Rx is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Metabolyz | Open Water Rx |
|---|---|---|
| WeighScore | 59.6/100 | 58.8/100 |
| Grade | C | C |
| Scorecard rank | #339 | #359 |
| Semaglutide | Not disclosed | $249/mo (compounded) |
| Tirzepatide | Not disclosed | $339/mo (compounded) |
| Coverage | All 50 states | Coverage not published |
| Brand-name access | Compounded only | Yes |
| Oral / sublingual | Injection only | Yes |
Graded #339 · C
Strengths
- Three GLP-1 programs: standard semaglutide, dual-agonist tirzepatide, and a microdose protocol for near-goal or dose-sensitive patients
- Nutrition, movement, and lifestyle coaching included in all programs at no extra charge
- Medication compounded in licensed 503A/503B US pharmacies with temperature-controlled, unmarked direct-to-door delivery
- Licensed provider supervision with direct messaging access and structured check-ins throughout
- Telehealth across all 50 states; BMI 27+ eligibility (25+ with weight-related condition)
Where it loses points
- Pricing is fully gated — not disclosed until after consultation, preventing upfront cost comparison
- Compounded GLP-1 only — no brand-name options (Wegovy, Zepbound) available
- No LegitScript certification or named medical leadership found on public-facing pages
- Labs not mentioned as included — unclear whether baseline or follow-up bloodwork is offered
- Newer brand with no external reviews, published outcomes data, or notable accreditations
Graded #359 · C
Strengths
- Combines weight-loss and longevity verticals in one brand
- Established brand domain
Where it loses points
- Limited public data — most details are gated behind signup or rendered only in JavaScript
- Pricing not disclosed
- GLP-1 options (semaglutide vs. tirzepatide, compounded vs. brand, injection vs. oral) not stated
- States-served list not disclosed
- Pharmacy partner not named
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.