Head-to-head · WeighScore
Loop Health vs Ryze Rx
The verdict
Loop Health takes it — 64.2/100 to 58.2/100.
Loop Health grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Loop Health is a US telehealth membership platform offering compounded semaglutide and tirzepatide under its Loop Lean program, alongside peptides, NAD+, sermorelin, coaching, and bloodwork.
We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.
Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Loop Health | Ryze Rx |
|---|---|---|
| WeighScore | 64.2/100 | 58.2/100 |
| Grade | C | C |
| Scorecard rank | #244 | #376 |
| Semaglutide | $199/mo (all doses, microdosed, membership required, compounded) | $199/mo (starting dose, 3 month plan, compounded) |
| Tirzepatide | $299/mo (all doses, microdosed, membership required, compounded) | $199/mo (starting dose, 3 month plan, compounded) |
| Coverage | All 50 states | Coverage not published |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Injection only |
Graded #244 · C
Strengths
- Multi-product wellness platform — GLP-1 plus peptides, NAD+, coaching, bloodwork
- Low membership entry point ($79/mo)
- Annual plan includes monthly 'research credit' toward compounds
- Explicit compounded-drug FDA disclaimer on-site
Where it loses points
- The medication price is on top of a $1,500-a-year membership, annual-plan only, which the terms confirm is separate from compound and medication costs
- Everything sold here is microdosed — the banner over both products reads 'MICRODOSED GLP-1', which is not a labelled therapeutic dose
- The prices exist only after the page's JavaScript runs; the served HTML body is empty
- Compounded semaglutide and tirzepatide are not FDA-approved finished products
Graded #376 · C
Strengths
- Compounded semaglutide and tirzepatide both $199/mo, with $499/$799 three-month bundles
- Physician consultation, ongoing clinical support and discreet shipping included with each prescription
- Broad catalog beyond GLP-1: TRT plus peptides (BPC-157, sermorelin, NAD+, retatrutide and more)
- Free shipping, 24hr prescription turnaround, FSA/HSA eligible; care advertised in all 50 states
Where it loses points
- Terms, Privacy Policy and HIPAA notice are dead links - no legal entity, refund policy or governing law disclosed
- Pharmacy partners not named - only 'US-licensed compounding pharmacies'
- Homepage advertises GLP-1s 'from $149/mo' but the catalog lists $199/mo
- On-site '4.9/5, 2,400+ reviews' is self-reported, not an independently verified rating
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.