Head-to-head · WeighScore
Knownwell vs PlexusDx
The verdict
PlexusDx takes it — 67.7/100 to 66.9/100, but only just.
PlexusDx grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. PlexusDx (plexusdx.com) is a US GLP-1 telehealth platform offering compounded weight-loss medications with licensed providers in all 50 states. Knownwell is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Knownwell | PlexusDx |
|---|---|---|
| WeighScore | 66.9/100 | 67.7/100 |
| Grade | C | C |
| Scorecard rank | #180 | #161 |
| Semaglutide | Not disclosed | $149/mo (starting dose, compounded) |
| Tirzepatide | $349/mo (brand Zepbound) | $249/mo (starting dose, compounded) |
| Coverage | All 50 states | All 50 states |
| Brand-name access | Yes | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #180 · C
Strengths
- Co-founded by obesity-medicine specialist Dr. Angela Fitch
- Branded FDA-approved GLP-1s (Wegovy, Zepbound, Ozempic, Saxenda)
- Official LillyDirect provider and Novo Wegovy-pill telehealth partner
- Accepts insurance, copays as low as $25 for covered patients
- Weight-inclusive care with dietitians and health coaches
Where it loses points
- Specific self-pay monthly medication prices not transparently posted
- In-person clinics limited to four metro areas
- Branded-only focus can mean higher cost than compounded routes
Graded #161 · C
Strengths
- Licensed providers available in all 50 states
- Range of options including low-cost microdose GLP-1 from $129/mo
- Optional Precision Peptide genetic panel adds a personalization angle
- Independent clinician review via state-licensed telehealth platform
- Compounded medications from state-licensed pharmacies
Where it loses points
- Compounded medications only; no FDA-approved brand options
- Specific compounding pharmacies not named
- Genetic-panel upsell may not add clinical value for everyone
- Tirzepatide pricing from $249/mo is higher than budget rivals
- No insurance accepted
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.