Head-to-head · WeighScore
DrBrainRx vs Fifty 410
The verdict
Fifty 410 takes it — 71.3/100 to 70.8/100, but only just.
Fifty 410 grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Fifty 410 is a direct-to-consumer weight-loss telehealth service offering personalized compounded semaglutide and tirzepatide prescribed by licensed providers and prepared by FDA-registered 503A and 503B… DrBrainRx is close behind and may still be the better fit — see the factor split below.
We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.
Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | DrBrainRx | Fifty 410 |
|---|---|---|
| WeighScore | 70.8/100 | 71.3/100 |
| Grade | C | C |
| Scorecard rank | #102 | #94 |
| Semaglutide | $199/mo (all doses, compounded) | $99/mo (all doses, compounded) |
| Tirzepatide | $299/mo (all doses, compounded) | $133/mo (starting dose, compounded) |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Injection only |
Graded #102 · C
Strengths
- Founded and overseen by Dr. Sara Siavoshi — triple board-certified in Neurology, Headache Medicine, and Obesity Medicine
- LegitScript certified with compounded medications from USP-certified 503B pharmacies
- Flat-rate pricing — same monthly cost for all dose levels (dose escalation does not raise price)
- 100% online with rapid approvals (~24-48 hours) and discreet shipping in 3–5 business days
- Side-effect support, dose adjustments, and injection guides included with provider care
Where it loses points
- Separate $25/month provider care fee (compounded track) on top of medication cost
- Compounded medications are not FDA-approved individual drugs
- Labs not required or included — no baseline bloodwork protocol disclosed
- States served not published; no explicit list available
- No dedicated coaching program beyond clinical dose management
Graded #94 · C
Strengths
- Transparent public pricing from 99 dollars per month for semaglutide
- No membership or subscription; pay only for what you need
- Compounded by FDA-registered 503A and 503B pharmacies
- Fast 24 to 48 hour provider review
- Free one to two day shipping
Where it loses points
- Does not bill insurance directly
- Compounded GLP-1 is not an FDA-approved finished drug
- Specific clinician credentials are not publicly disclosed
- Served-states list is not published on the site
- No branded GLP-1 options
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.