Head-to-head · WeighScore
Defy Medical vs Next Vial
The verdict
Defy Medical takes it — 60.2/100 to 59.3/100, but only just.
Defy Medical grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Defy Medical is a long-running telehealth clinic, best known for hormone replacement, that also prescribes GLP-1 medications for weight loss. Next Vial is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Defy Medical | Next Vial |
|---|---|---|
| WeighScore | 60.2/100 | 59.3/100 |
| Grade | C | C |
| Scorecard rank | #325 | #345 |
| Semaglutide | Not disclosed | $250/mo (compounded) |
| Tirzepatide | Not disclosed | Not disclosed |
| Coverage | Coverage not published | 49 states |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #325 · C
Strengths
- Multiple GLP-1 options: semaglutide, tirzepatide, liraglutide
- Offers injection, ODT, and oral drop delivery forms
- Comprehensive blood testing and named medical director
- Established clinic with strong Trustpilot review volume
Where it loses points
- GLP-1 pricing not published on the website
- States served and shipping limits not disclosed
- Compounded versus brand status not stated online
- Lab-heavy, consult-first model may cost more upfront
Graded #345 · C
Strengths
- LegitScript verified with named pharmacy partner (Manifest Pharmacy, Greer, SC)
- No membership fees — one all-in price covering consultation, medication, and shipping
- Compounded semaglutide, tirzepatide, and microdose options available
- Free rushed shipping; serves 49 states nationwide
- Board-certified physician oversight with ongoing provider support
Where it loses points
- Tirzepatide pricing not listed publicly (starting price covers GLP-1 generally)
- Compounded medications are not FDA-approved
- Labs and nutritional coaching not disclosed
- Microdose pricing not published on product page
- Alaska not listed among served states
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.