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Head-to-head · WeighScore

Defy Medical vs Lean Rx

Defy Medical
Graded #325

Lower grade

vs+0.3999999999999986
Lean Rx
Graded #318

Higher grade

The verdict

Lean Rx takes it — 60.6/100 to 60.2/100, but only just.

Lean Rx grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Lean Rx is a Sacramento-based telehealth technology platform offering compounded GLP-1 weight loss medications. Defy Medical is close behind and may still be the better fit — see the factor split below.

We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.

Factor by factor

The same six graded dimensions, side by side. See the methodology.

Cost valueDefy Medical +5
45
40
Dose & formulationLean Rx +19
56
75
Clinical oversightLean Rx +1
80
81
Labs & monitoringDefy Medical +13
65
52
FulfillmentDefy Medical +3
63
60
Contract termsEven
55
55
Defy Medical · left barLean Rx · right bar

The numbers

MetricDefy MedicalLean Rx
WeighScore60.2/10060.6/100
GradeCC
Scorecard rank#325#318
SemaglutideNot disclosed$266/mo (starting dose, compounded)
TirzepatideNot disclosed$399/mo (starting dose, compounded)
CoverageCoverage not publishedCoverage not published
Brand-name accessCompounded onlyCompounded only
Oral / sublingualYesYes
Defy Medical

Graded #325 · C

Strengths

  • Multiple GLP-1 options: semaglutide, tirzepatide, liraglutide
  • Offers injection, ODT, and oral drop delivery forms
  • Comprehensive blood testing and named medical director
  • Established clinic with strong Trustpilot review volume

Where it loses points

  • GLP-1 pricing not published on the website
  • States served and shipping limits not disclosed
  • Compounded versus brand status not stated online
  • Lab-heavy, consult-first model may cost more upfront
Lean Rx

Graded #318 · C

Strengths

  • Both semaglutide and tirzepatide offered
  • Three formulations: injectable, sublingual, and tablet
  • Upfront pricing with no hidden fees advertised
  • Semaglutide starts at a low $266/month
  • Telehealth call with a licensed provider before prescribing

Where it loses points

  • Compounded-only; no FDA-approved branded options
  • No published state availability list
  • Platform is technology only, not a healthcare provider itself
  • Provider credentials not detailed on site

Also worth a look

Neither is our top-graded pick — CoreAge Rx leads the scorecard

Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.

Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.

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