Head-to-head · WeighScore
CaliberRx vs Lyfe Rx
The verdict
CaliberRx takes it — 58.5/100 to 58.3/100, but only just.
CaliberRx grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. CaliberRx is a 100% online telehealth platform offering compounded GLP-1 weight-loss treatment — semaglutide and tirzepatide — prescribed by licensed clinicians after an online medical-history review. Lyfe Rx is close behind and may still be the better fit — see the factor split below.
We may earn a commission if you start care through some of these links, at no extra cost to you. It never moves the WeighScore, which is the weighted average of the six factors shown for every provider, and what we write about a provider is the same either way. See our disclosure.
Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | CaliberRx | Lyfe Rx |
|---|---|---|
| WeighScore | 58.5/100 | 58.3/100 |
| Grade | C | C |
| Scorecard rank | #370 | #375 |
| Semaglutide | Not disclosed | $225/mo (compounded) |
| Tirzepatide | Not disclosed | $299/mo (compounded) |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Injection only |
Graded #370 · C
Strengths
- Compounded GLP-1 — semaglutide and tirzepatide — prescribed by licensed clinicians after an online medical-history review
- 100% online with free, discreet delivery and 24/7 medical support; no insurance required
- Unusually thorough legal/compliance suite (privacy practices, telehealth consent, state-privacy addendum, refund, billing, program disclaimers)
- Personalized plan written by a licensed provider based on your individualized assessment
Where it loses points
- Pricing is not published — it is shown only after you complete the intake quiz
- Compounded GLP-1s are not FDA-approved, and the compounding pharmacy is not named
- State-availability list is not published
- No LegitScript certification displayed
Graded #375 · C
Strengths
- Both compounded semaglutide and tirzepatide available
- Delivery to all 50 states with 1–3 day pharmacy turnaround
Where it loses points
- No visible LegitScript or PCAB accreditation
- Also sells non-prescription supplements ('Tirzepatide Weight Loss Supplement', 'Lipo Burn')
- Shopify-based e-commerce storefront — less clinical infrastructure
- FDA issued this company a warning letter dated 9 September 2025; the letter is public in FDA's warning-letter database
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.