Head-to-head · WeighScore
Blue Sky MD vs PlexusDx
The verdict
PlexusDx takes it — 67.7/100 to 67.5/100, but only just.
PlexusDx grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. PlexusDx (plexusdx.com) is a US GLP-1 telehealth platform offering compounded weight-loss medications with licensed providers in all 50 states. Blue Sky MD is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Blue Sky MD | PlexusDx |
|---|---|---|
| WeighScore | 67.5/100 | 67.7/100 |
| Grade | C | C |
| Scorecard rank | #170 | #161 |
| Semaglutide | $160/mo (starting dose, compounded) | $149/mo (starting dose, compounded) |
| Tirzepatide | $240/mo (starting dose, compounded) | $249/mo (starting dose, compounded) |
| Coverage | 1 states | All 50 states |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Injection only |
Graded #170 · C
Strengths
- LegitScript certified and physician-led since 2008; one of the most established GLP-1 practices in the Southeast
- Compounded semaglutide from $40/week (~$160/month) and tirzepatide from $60/week (~$240/month) — well below brand-name cost
- Comprehensive program includes 1-on-1 wellness coaching, nutrition plans, hormone analysis, and a proprietary mobile app
- Medication shipped directly to patients’ homes within 3–5 business days; telehealth visits available
- Insurance accepted in many cases; affordable self-pay options for uninsured patients
Where it loses points
- Geographic reach unclear — physical clinics in NC only; telehealth states beyond NC unconfirmed despite 'from virtually anywhere' claim
- Pricing quoted per-week ($40 sema / $60 tirz) rather than per-month; higher-dose pricing not disclosed
- Must enroll in full medical weight-loss program to access GLP-1 medications — medication-only Rx not offered
- No explicit lab testing protocol published; online FAQ does not confirm labs are included
- Small regional provider vs. national platforms; limited provider footprint outside North Carolina
Graded #161 · C
Strengths
- Licensed providers available in all 50 states
- Range of options including low-cost microdose GLP-1 from $129/mo
- Optional Precision Peptide genetic panel adds a personalization angle
- Independent clinician review via state-licensed telehealth platform
- Compounded medications from state-licensed pharmacies
Where it loses points
- Compounded medications only; no FDA-approved brand options
- Specific compounding pharmacies not named
- Genetic-panel upsell may not add clinical value for everyone
- Tirzepatide pricing from $249/mo is higher than budget rivals
- No insurance accepted
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.