Head-to-head · WeighScore
Ascend Vitality vs Knownwell
The verdict
Knownwell takes it — 66.9/100 to 60.9/100.
Knownwell grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Knownwell is a weight-inclusive metabolic and primary care company co-founded by obesity-medicine specialist Dr.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | Ascend Vitality | Knownwell |
|---|---|---|
| WeighScore | 60.9/100 | 66.9/100 |
| Grade | C | C |
| Scorecard rank | #307 | #172 |
| Semaglutide | $199/mo (compounded) | Not disclosed |
| Tirzepatide | $299/mo (compounded) | $349/mo (brand Zepbound) |
| Coverage | Coverage not published | All 50 states |
| Brand-name access | Compounded only | Yes |
| Oral / sublingual | Yes | Yes |
Graded #307 · C
Strengths
- Both injectable and needle-free oral tablet forms of semaglutide and tirzepatide
- LegitScript certified
- Transparent cash-pay pricing with cancel-anytime subscription
- Legal entity and address publicly disclosed (Ascend Vitality LLC, Sheridan, WY)
Where it loses points
- All medications are compounded — FDA does not review compounded drugs for safety/effectiveness
- No named compounding pharmacy partner disclosed
- No public state-by-state availability list (homepage cites exclusions: LA, MS, KS, NM, WV)
- Per-dose/titration pricing not published; only 'starting at' prices shown
Graded #172 · C
Strengths
- Co-founded by obesity-medicine specialist Dr. Angela Fitch
- Branded FDA-approved GLP-1s (Wegovy, Zepbound, Ozempic, Saxenda)
- Official LillyDirect provider and Novo Wegovy-pill telehealth partner
- Accepts insurance, copays as low as $25 for covered patients
- Weight-inclusive care with dietitians and health coaches
Where it loses points
- Specific self-pay monthly medication prices not transparently posted
- In-person clinics limited to four metro areas
- Branded-only focus can mean higher cost than compounded routes
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.