Head-to-head · WeighScore
AlyveRx vs Fifty 410
The verdict
Fifty 410 takes it — 71.3/100 to 70.3/100, but only just.
Fifty 410 grades higher on WeighScore, our editorial score across cost value, dose & formulation, clinical oversight, labs & monitoring, fulfillment and contract terms. Fifty 410 is a direct-to-consumer weight-loss telehealth service offering personalized compounded semaglutide and tirzepatide prescribed by licensed providers and prepared by FDA-registered 503A and 503B… AlyveRx is close behind and may still be the better fit — see the factor split below.
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Factor by factor
The same six graded dimensions, side by side. See the methodology.
The numbers
| Metric | AlyveRx | Fifty 410 |
|---|---|---|
| WeighScore | 70.3/100 | 71.3/100 |
| Grade | C | C |
| Scorecard rank | #107 | #95 |
| Semaglutide | $183/mo (all doses, compounded) | $99/mo (all doses, compounded) |
| Tirzepatide | $249/mo (all doses, compounded) | $133/mo (starting dose, compounded) |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Yes | Compounded only |
| Oral / sublingual | Yes | Injection only |
Graded #107 · C
Strengths
- Offers compounded semaglutide and tirzepatide as both injections and needle-free sublingual drops for people who dislike needles
- Transparent monthly pricing shown upfront, no insurance required, and free discreet delivery
- Also carries brand-name Ozempic, Wegovy, and Mounjaro through its provider network
Where it loses points
- Does not publicly name its dispensing pharmacy or display a LegitScript seal, so third-party accreditation is unverified
- Sublingual GLP-1 absorption relies on the company proprietary PermeAct technology and is not FDA-reviewed for weight loss
- State availability is not published on the site
Graded #95 · C
Strengths
- Transparent public pricing from 99 dollars per month for semaglutide
- No membership or subscription; pay only for what you need
- Compounded by FDA-registered 503A and 503B pharmacies
- Fast 24 to 48 hour provider review
- Free one to two day shipping
Where it loses points
- Does not bill insurance directly
- Compounded GLP-1 is not an FDA-approved finished drug
- Specific clinician credentials are not publicly disclosed
- Served-states list is not published on the site
- No branded GLP-1 options
Also worth a look
Neither is our top-graded pick — CoreAge Rx leads the scorecard
Across all 499 providers, CoreAge Rx grades highest at 91.8/100 (A−). Top of the scorecard: flat transparent pricing, both molecules, nationwide — no teaser-rate games.
Pricing/verification reflect each provider's public disclosures at last grading; the WeighScore is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.